Students will attend Dynamics of Self-Organization in Animal and Plant Development program talks each morning and spend afternoons and evenings working in their lab groups and attending modeling and analysis tutorials. Confirmed program participants include Dominique Bergmann (Stanford), James Briscoe (Crick Inst.), Francis Corson (ENS Paris), Cassandra Extavour (Harvard), Ken Irvine (Rutgers), Thomas Lecuit (College de France/IBDM), Ani Kicheva (IST Austria), Prisca Liberali (FMI), Adam Martin (MIT), Elliot Meyerowitz (Caltech), Rashmi Priya (Crick Inst.), Sharad Ramanathan (Harvard), Jochen Rink (MPI-NAT), Adrienne Roeder (Cornell), Timothy Saunders (Warwick), Eric Siggia (Rockefeller), Katharina Sonnen (Hubrecht Inst.), David Sprinzak (Tel Aviv), and Aryeh Warmflash (Rice). Students and lecturers will also have frequent opportunities for less formal interactions. The summer course is closely linked to the concurrent KITP program Dynamics of Self-Organization in Animal and Plant Development. Course participants will attend the program's daily research seminars as part of the course curriculum. of Michigan), Kinneret Keren (Technion), Alan Rodrigues (Rockefeller ), Amy Shyer (Rockefeller), and Vikas Trivedi (EMBL Barcelona) Experimental systems include the mechanobiology of human embryonic stem cell patterning, mechanical pattern formation in the avian dermis, synthetic morphogenesis with mouse as well as human embryonic stem cell lines, and the regenerative model system hydra. This course will study synthetic morphogenesis by integrating quantitative data analysis and mathematical modeling, in a variety of hands-on projects.
Recent progress with stem cell culture now enables addressing fundamental questions of developmental biology, about the interplay of mechanics, biochemical patterning, and geometry. Culturing techniques enable precise regulation and measurements of biochemical factors, as well as physical, and geometric constraints. While superb genetic perturbations are readily available, physical analysis, such as measurements or even perturbation of mechanics, remains a high hurdle.Ĭell biology successfully incorporated experimental methods from physics and engineering into the study of immortalized cell lines.
These analyses rely on studying embryogenesis in model organisms such as the fruit fly, mouse, or zebrafish. Quantitative investigation of cellular flow in vivo indicates that feedback mechanisms between genetics, mechanical force generation, and geometry ensure a robust and reproducible time course of shape. Molecular analysis uncovered how the basic architecture of the body plan is laid out and how genetic patterning instructs cell fate. Animal morphogenesis, the question of how body parts acquire their form, remains a fascinating open problem of developmental biology and physics.
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